4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one - Names and Identifiers
Name | 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one
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Synonyms | Decitabine Impurity 37 Decitabine Related Compound C Decitabine Impurity 3(Decitabine USP RC C) 4-amino-1-[3,5-di-O-(p-chlorobenzoyl)]-2-deoxy-alpha-D-ribofuranosyl-1,3,5-triazin-2(1H)-one 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-alpha-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one
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CAS | 1140891-02-6
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4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one - Physico-chemical Properties
Molecular Formula | C22H18Cl2N4O6
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Molar Mass | 505.31 |
Melting Point | >200°C (dec.) |
Solubility | Dichloromethane (Slightly, Heated), DMSO (Slightly, Heated, Sonicated), Methanol |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one - Introduction
4-Amino -1-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3, 5-Triazin-2 (1H)-one is an organic compound with the following properties:
Nature:
1. Chemical formula: C22H17ClN4O7
2. Molecular Weight: 498.84g/mol
3. Appearance: white or white crystalline powder
4. Solubility: slightly soluble in water, soluble in organic solvents such as chloroform, dichloromethane, etc.
Use:
This compound is a nucleoside antiviral drug commonly used in the treatment of HIV infection. It is a reverse transcriptase inhibitor that inhibits viral DNA synthesis, thereby reducing viral replication and transmission.
Preparation Method:
The preparation method of this compound is more complicated, and it is generally synthesized by organic synthesis reaction. Specific synthetic pathways involve multi-step reactions, including selective protection reactions, substitution reactions, deprotection reactions, and the like.
Safety Information:
1. 4-Amino -1-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl]-1,3, 5-Triazin-2 (1H)-one is a toxic compound. Use should pay attention to protective measures, avoid contact with skin, eyes and respiratory tract.
2. During operation, Good Laboratory safety practices should be followed, appropriate protective equipment should be worn, and good ventilation should be ensured.
3. The compound should be stored in a dry, cool, dark place, away from fire and flammable substances.
Last Update:2024-04-09 02:00:54